Trustworthy Machine Learning Predictions to Support Clinical Research and Decisions

Nowadays, physicians have at their hands a huge amount of data produced by a large set of diagnostic and instrumental tests integrated with data obtained by high-throughput technologies. If such data were opportunely linked and analysed, they might be used to strengthen predictions, so that to improve the prevention and the time-to-diagnosis, reduce the costs of the health system, and bring out hidden knowledge. Machine learning is the principal technique used nowadays to leverage data and gain useful information. However, it has led to various challenges, such as improving the interpretability and explainability of the employed predictive models and integrating expert knowledge into the final system. Solving those challenges is of paramount importance to enhance the trust of both clinicians and patients in the system predictions. To solve the aforementioned issues, in this paper we propose a software workflow able to cope with the trustworthiness aspects of machine learning models and considering a multitude of heterogeneous data and models.