Purpose: We investigated sex-related brain metabolic differences in Amyotrophic Lateral Sclerosis (ALS) and healthy controls (HC). Methods: We collected two equal-sized groups of male (m-ALS) and female ALS (f-ALS) patients (n = 130 each), who underwent 2-[18F]FDG-PET at diagnosis, matched for site of onset, cognitive status and King's stage. We included 168 age-matched healthy controls, half female (f-HC) and half male (m-HC). We compared brain metabolism of males and females separately for ALS and HC, including age as covariate. A differential network analysis was performed to evaluate brain connectivity. Results: M-ALS showed relative hypometabolism of bilateral medial frontal, parietal and occipital cortices, and left temporal cortex, compared to f-ALS. In node-wise comparison, f-ALS showed significantly higher connectivity in right middle cingulate cortex and left superior and medial frontal gyrus. In HC we did not find any sex-related differences. Conclusion: Sex resulted a major determinant of brain metabolism and connectivity in ALS patients.
Sex-related differences in amyotrophic lateral sclerosis: A 2-[18F]FDG-PET study / Canosa, Antonio; Martino, Alessio; Manera, Umberto; Giuliani, Alessandro; Vasta, Rosario; Palumbo, Francesca; Grassano, Maurizio; Morbelli, Silvia Daniela; Pardini, Matteo; Chiaravalloti, Agostino; Schillaci, Orazio; Leenders, Klaus Leonard; Kogan, Rosalie Vered; Polverari, Giulia; Zocco, Grazia; Pede, Francesca Di; Mattei, Filippo De; Cabras, Sara; Matteoni, Enrico; Moglia, Cristina; Calvo, Andrea; Chiò, Adriano; Pagani, Marco. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1468-1331. - 32:1(2025), pp. 1-11. [10.1111/ene.16588]
Sex-related differences in amyotrophic lateral sclerosis: A 2-[18F]FDG-PET study
Martino, Alessio;
2025
Abstract
Purpose: We investigated sex-related brain metabolic differences in Amyotrophic Lateral Sclerosis (ALS) and healthy controls (HC). Methods: We collected two equal-sized groups of male (m-ALS) and female ALS (f-ALS) patients (n = 130 each), who underwent 2-[18F]FDG-PET at diagnosis, matched for site of onset, cognitive status and King's stage. We included 168 age-matched healthy controls, half female (f-HC) and half male (m-HC). We compared brain metabolism of males and females separately for ALS and HC, including age as covariate. A differential network analysis was performed to evaluate brain connectivity. Results: M-ALS showed relative hypometabolism of bilateral medial frontal, parietal and occipital cortices, and left temporal cortex, compared to f-ALS. In node-wise comparison, f-ALS showed significantly higher connectivity in right middle cingulate cortex and left superior and medial frontal gyrus. In HC we did not find any sex-related differences. Conclusion: Sex resulted a major determinant of brain metabolism and connectivity in ALS patients.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Euro J of Neurology - 2024 - Canosa - Sexâ related differences in amyotrophic lateral sclerosis A 2â 18F FDGâ PET study.pdf
Open Access
Tipologia:
Versione dell'editore
Licenza:
Creative commons
Dimensione
1.19 MB
Formato
Adobe PDF
|
1.19 MB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
