The role performed by a protein is directly connected to its physico-chemical structure. How the latter affects the behaviour of these molecules is still an open research topic. In this paper we consider a subset of the Escherichia Coli proteome where each protein is represented through the spectral characteristics of its residue contact network and its physiological function is encoded by a suitable class label. By casting this problem as a machine learning task, we aim at assessing whether a relation exists between such spectral properties and the protein’s function. To this end we adopted a set of supervised learning techniques, possibly optimised by means of genetic algorithms. First results are promising and they show that such high-level spectral representation contains enough information in order to discriminate among functional classes. Our experiments pave the way for further research and analysis.

Supervised approaches for function prediction of proteins contact networks from topological structure information / Martino, Alessio; Maiorino, Enrico; Giuliani, Alessandro; Giampieri, Mauro; Rizzi, Antonello. - 10269:(2017), pp. 285-296. [10.1007/978-3-319-59126-1_24]

Supervised approaches for function prediction of proteins contact networks from topological structure information

MARTINO, ALESSIO
;
2017

Abstract

The role performed by a protein is directly connected to its physico-chemical structure. How the latter affects the behaviour of these molecules is still an open research topic. In this paper we consider a subset of the Escherichia Coli proteome where each protein is represented through the spectral characteristics of its residue contact network and its physiological function is encoded by a suitable class label. By casting this problem as a machine learning task, we aim at assessing whether a relation exists between such spectral properties and the protein’s function. To this end we adopted a set of supervised learning techniques, possibly optimised by means of genetic algorithms. First results are promising and they show that such high-level spectral representation contains enough information in order to discriminate among functional classes. Our experiments pave the way for further research and analysis.
2017
978-3-319-59126-1
pattern recognition
supervised learning
support vector machines
protein contact networks
normalized laplacian matrix
Supervised approaches for function prediction of proteins contact networks from topological structure information / Martino, Alessio; Maiorino, Enrico; Giuliani, Alessandro; Giampieri, Mauro; Rizzi, Antonello. - 10269:(2017), pp. 285-296. [10.1007/978-3-319-59126-1_24]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11385/214478
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