In reconstructing the common evolutionary history of hosts and parasites, the current method of choice is the phylogenetic tree reconciliation. In this model, we are given a host tree H, a parasite tree P, and a function σ mapping the leaves of P to the leaves of H and the goal is to find, under some biologically motivated constraints, a reconciliation, that is a function from the vertices of P to the vertices of H that respects σ and allows the identification of biological events such as co-speciation, duplication and host switch. The maximum co-divergence problem consists in finding the maximum number of co-speciations in a reconciliation. This problem is NP-hard for arbitrary phylogenetic trees and no approximation algorithm is known. In this paper we consider the influence of tree topology on the maximum co-divergence problem. In particular we focus on a particular tree structure, namely caterpillar, and show that—in this case—the heuristics that are mostly used in the literature provide solutions that can be arbitrarily far from the optimal value. Then, we prove that finding the max co-divergence is equivalent to compute the maximum length of a subsequence with certain properties of a given permutation. This equivalence leads to two consequences: (1) it shows that we can compute efficiently in polynomial time the optimal time-feasible reconciliation and (2) it can be used to understand how much the tree topology influences the value of the maximum number of co-speciations.
Autori: | |
Autori: | Calamoneri, T.; Monti, A.; Sinaimeri, Blerina |
Data di pubblicazione: | 2019 |
Stato del documento: | Pubblicato |
Presenza coautori internazionali: | no |
Titolo: | Co-divergence and tree topology |
Numero degli autori: | 3 |
Revisione (peer review): | Esperti anonimi |
Rilevanza: | Internazionale |
Lingua: | Inglese |
Rivista: | |
Volume: | 79 |
Fascicolo: | 3 |
Pagina iniziale: | 1149 |
Pagina finale: | 1167 |
Numero di pagine: | 19 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00285-019-01385-w |
Categorie ISI-CRUI: | Computer Science and Engineering includes resources on computer hardware and architecture, computer software, software engineering and design, computer graphics, programming languages, theoretical computing, computing methodologies, broad computing topics, and interdisciplinary computer applications. Engineering Mathematics covers resources on applied mathematics, mathematical modelling, combinatorics, optimization techniques, numerical methods, and statistical methods that have an emphasis on engineering systems. |
Parole Chiave: | caterpillars; co-phylogeny; reconciliations |
Produzione editoriale LUISS: | no |
Codice identificativo Scopus: | 2-s2.0-85067811907 |
Codice identificativo ISI: | WOS:000477980100012 |
Data di presentazione: | 2021-02-04T14:40:59Z |
Abstract: | In reconstructing the common evolutionary history of hosts and parasites, the current method of choice is the phylogenetic tree reconciliation. In this model, we are given a host tree H, a parasite tree P, and a function σ mapping the leaves of P to the leaves of H and the goal is to find, under some biologically motivated constraints, a reconciliation, that is a function from the vertices of P to the vertices of H that respects σ and allows the identification of biological events such as co-speciation, duplication and host switch. The maximum co-divergence problem consists in finding the maximum number of co-speciations in a reconciliation. This problem is NP-hard for arbitrary phylogenetic trees and no approximation algorithm is known. In this paper we consider the influence of tree topology on the maximum co-divergence problem. In particular we focus on a particular tree structure, namely caterpillar, and show that—in this case—the heuristics that are mostly used in the literature provide solutions that can be arbitrarily far from the optimal value. Then, we prove that finding the max co-divergence is equivalent to compute the maximum length of a subsequence with certain properties of a given permutation. This equivalence leads to two consequences: (1) it shows that we can compute efficiently in polynomial time the optimal time-feasible reconciliation and (2) it can be used to understand how much the tree topology influences the value of the maximum number of co-speciations. |
Campo Ausiliario 4: | no |
Campo Ausiliario 3: | Non legato ad alcun Centro di ricerca |
Appare nelle tipologie: | 01.1 - Articolo su rivista (Article) |
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